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Synfacts 2007(7): 0667-0667  
DOI: 10.1055/s-2007-968596
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Δ 9-trans-Tetrahydrocannabinol

Contributor(s): Philip Kocienski, Indu Dager
B. M. Trost*, K. Dogra
Stanford University, USA
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

(-)-Δ 9-trans-Tetrahydrocannabinol, isolated from female Cannabis sativa L., exhibits a plethora of bioactivities. Noteworthy in this short and efficient synthesis is a Mo-catalyzed asymmetric allylic alkylation reaction.